Lupron Depot-Ped

Generic name: leuprolide [ LOO-proe-lide ]
Brand names: Camcevi, Eligard, Fensolvi, Lupron Depot, Lupron Depot-Ped
Drug classes: Gonadotropin releasing hormones, Hormones / antineoplastics

Medically reviewed by Drugs.com on Oct 17, 2023. Written by Cerner Multum.

What is Lupron Depot-Ped?

Lupron Depot-Ped is used in adult males to treat the symptoms associated with advanced prostate cancer. This medicine is used in adult females alone or in combination to treat endometriosis (overgrowth of uterine lining outside of the uterus) or in combination with iron therapy to treat anemia caused by uterine fibroids.

Lupron Depot-Ped is also used to treat precocious (early-onset) puberty in both male and female children at least 2 years old.

Lupron Depot-Ped may also be used for purposes not listed in this medication guide.

Lupron Depot-Ped side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have a seizure, unusual changes in mood or behavior (crying spells, irritability, restlessness, anger, aggression), severe headaches, ringing in your ears, dizziness, nausea, vision problems, or pain behind your eyes.

Your symptoms may become temporarily worse when you first start using Lupron Depot-Ped, including new or worsening symptoms of sexual development in children. Tell your doctor if this continues for longer than 2 months.

Lupron Depot-Ped may cause serious side effects. Call your doctor at once if you have:

• bone pain, loss of movement in any part of your body;

• swelling, rapid weight gain;

• a seizure;

• unusual changes in mood or behavior (crying spells, anger, feeling irritable);

• sudden chest pain or discomfort, wheezing, dry cough or hack;

• painful or difficult urination;

• pain or unusual sensations in your back, numbness, weakness, or tingly feeling in your legs or feet;

• muscle weakness or loss of muscle use, loss of bladder or bowel control;

• problems with your pituitary gland--sudden severe headache, vomiting, problems with your eyes or vision, changes in mood or behavior;

• high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor;

• heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or

• signs of a stroke--sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance.

Common side effects of Lupron Depot-Ped may include:

• pituitary gland problems;

• acne, itching, rash, white scales (seborrhea);

• cold symptoms such as stuffy nose, sneezing, sore throat, cough with or without mucus;

• fractures, ligament sprain;

• fever, tiredness, not feeling well;

• stomach pain, nausea, vomiting, diarrhea, constipation;

• wheezing, chest tightness, trouble breathing;

• breast tenderness, hot flashes, sweating;

• dizziness, sleep problems, mood changes;

• headache, general pain;

• vaginal swelling, itching, or discharge;

• weight changes;

• decreased testicle size;

• irregular menstrual periods, decreased interest in sex; or

• redness, pain, swelling, or oozing where the medicine was injected.

Lupron Depot-Ped can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using Lupron Depot-Ped.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

tamoxifen, leuprolide, Nolvadex, triptorelin, Soltamox

Warnings

Your symptoms may become temporarily worse when you first start using Lupron Depot-Ped, including new or worsening symptoms of sexual development in children. Tell your doctor if this continues for longer than 2 months.

Call your doctor at once if you have a seizure, unusual changes in mood or behavior, severe headaches, ringing in your ears, dizziness, nausea, vision problems, or pain behind your eyes.

Do not use if you are pregnant. Use effective birth control. Do not use if you have abnormal vaginal bleeding that has not been checked by a doctor.

Before taking this medicine

You should not use Lupron Depot-Ped if you are allergic to Lupron Depot-Ped or similar medicines such as buserelin, goserelin, histrelin, nafarelin, or if you have abnormal vaginal bleeding that has not been checked by a doctor.

Tell your doctor if you have or have ever had:

• depression, mental illness, or psychosis;

• seizures or epilepsy;

• a blood vessel disorder;

• a brain tumor or spinal cord injury;

• heart disease, congestive heart failure, long QT syndrome;

• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or

• risk factors for bone loss (personal or family history of osteoporosis, smoking, alcohol use, taking steroid or seizure medicines long term).

Lupron Depot-Ped usually causes women to stop ovulating or having menstrual periods. However, you may still be able to get pregnant. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, or contraceptive sponge.

Call your doctor if your periods continue while you are being treated with this medicine.

May cause birth defects. Do not use if you are pregnant. Tell your doctor if you become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I use Lupron Depot-Ped?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

There are many brands, strengths, or forms of leuprolide used to treat different conditions. Avoid medication errors by using only the medicine your doctor prescribes.

Lupron Depot-Ped is usually administered by a healthcare provider.

Lupron Depot-Ped is injected under the skin or into a muscle, once every month or once every 3 to 6 months. A healthcare provider may teach you how to properly use the medication by yourself.

Your symptoms may become temporarily worse as your hormones adjust to Lupron Depot-Ped. A child using this medicine may have increased signs of puberty (such as vaginal bleeding) during the first weeks of treatment.

You may need frequent medical tests while using Lupron Depot-Ped.

Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Follow all storage instructions provided with Lupron Depot-Ped. Your pharmacist can provide more information about how to store this medicine.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose or miss an appointment for your injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Lupron Depot-Ped?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Lupron Depot-Ped?

Lupron Depot-Ped can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Other drugs may affect Lupron Depot-Ped, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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